029. PR3-ANCA STATUS FOLLOWING RITUXIMAB: A USEFUL BIOMARKER FOR RELAPSE PREDICTION IN ANCA-ASSOCIATED VASCULITIS
نویسندگان
چکیده
منابع مشابه
Rituximab in ANCA-associated vasculitis: a revolution?
On 19 April 2011, the US Food and Drug Administration (FDA) approved rituximab in combination with glucocorticosteroids for the treatment of two forms of anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV): granulomatosis with polyangiitis (Wegener’s) and microscopic polyangiitis. Rituximab is the first FDA approved drug for ANCA-associated vasculitis. It is to be expect...
متن کاملRituximab versus cyclophosphamide for ANCA-associated vasculitis.
BACKGROUND Cyclophosphamide and glucocorticoids have been the cornerstone of remission-induction therapy for severe antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis for 40 years. Uncontrolled studies suggest that rituximab is effective and may be safer than a cyclophosphamide-based regimen. METHODS We conducted a multicenter, randomized, double-blind, double-dummy, noninferior...
متن کاملPR3-ANCA-positive necrotizing multi-organ vasculitis following cocaine abuse.
A 22-year-old man with a history of cocaine abuse from 2003 to 2005 developed recurrent bleeding of the nasal septum and a progressive cough and dyspnoea. He was admitted to the intensive care unit because of fulminant pneumonia, impaired renal function and progressive general deterioration. While hospitalized, he developed cutaneous vasculitis, thrombosis of the right subclavian and right jugu...
متن کاملClinical implications of serum thrombomodulin in PR3-ANCA-associated vasculitis
BACKGROUND Vascular injury is the main mechanism in pathophysiology of PR3-ANCA-associated vasculitis. Soluble serum thrombomodulin (sTM) is a membrane-bound receptor for thrombin expressed by vascular endothelial cells. - OBJECTIVE The aim of study was to determine the blood levels of sTM in patients with PR3-ANCA-associated vasculitis. MATERIAL AND METHODS Twenty five patients with Wegene...
متن کاملGalactosylation and Sialylation Levels of IgG Predict Relapse in Patients With PR3-ANCA Associated Vasculitis
OBJECTIVE The objective of our study is to investigate the Fc glycosylation profiles of both antigen-specific IgG targeted against proteinase 3 (PR3-ANCA) and total IgG as prognostic markers of relapse in patients with Granulomatosis with Polyangiitis (GPA). METHODS Seventy-five patients with GPA and a PR3-ANCA rise during follow-up were included, of whom 43 patients relapsed within a median ...
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ژورنال
عنوان ژورنال: Rheumatology
سال: 2019
ISSN: 1462-0324,1462-0332
DOI: 10.1093/rheumatology/kez057.028